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DSIP (5MG)

Original price was: $64.00.Current price is: $43.00.

  • DSIP stands for Delta Sleep-Inducing Peptide.
  • A related peptide with similar properties is found in high concentrations in human mother’s milk.
  • DSIP supports the management of sleep disturbances.
  • It interacts with the nervous system to regulate sleep.
  • DSIP also affects the hormonal system, influencing various hormonal functions related to sleep.
  • Research suggests DSIP may play a role in promoting and maintaining healthy sleep patterns.

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Description

  • Delta Sleep Inducing: DSIP is named for its ability to promote delta sleep, which is a deep sleep stage associated with restorative functions and essential for overall sleep quality.
  • Presence in Human Mother’s Milk: DSIP is naturally found in significant concentrations in human mother’s milk, indicating its potential role in early development and health.
  • Support for Sleep Disturbances: It has been studied for its potential to alleviate sleep disturbances, including difficulties in falling asleep or maintaining deep sleep stages.
  • Neurological and Hormonal Support: DSIP interacts with the nervous system and hormonal pathways, potentially influencing stress responses, mood regulation, and other physiological processes.

How It Works

  • Targeting Brain Sites: DSIP acts on specific areas of the brain and brainstem associated with sleep regulation and relaxation. By targeting these sites, DSIP helps promote deep, restorative sleep.
  • Interaction with Hormones and Neurotransmitters: DSIP interacts with key hormones and neurotransmitters involved in sleep:
    • Serotonin: A neurotransmitter that promotes relaxation and contributes to sleep onset.
    • Melatonin: A hormone that regulates the sleep-wake cycle and promotes sleepiness.
    • GABA (Gamma-Aminobutyric Acid): An inhibitory neurotransmitter that reduces neuronal excitability, helping to induce relaxation and sleep.

    By modulating these substances, DSIP helps facilitate the processes of falling asleep and maintaining deep sleep stages.

  • Endocrine Function Enhancement: During sleep, DSIP has been observed to enhance endocrine functions, leading to increased releases of:
    • Growth Hormone: Important for growth, repair of tissues, and overall metabolic functions.
    • Thyroid Hormone: Essential for metabolism, energy regulation, and growth.
    • Testosterone: A hormone crucial for male reproductive health, muscle growth, and overall vitality.

Research Benefits

  • Improves Sleep Quality: DSIP targets brain sites involved in sleep regulation, promoting deep and restorative sleep.
  • Reduces Chronic Pain: By promoting relaxation and possibly modulating pain perception pathways, DSIP may help alleviate chronic pain symptoms.
  • Fights Stress: DSIP’s interaction with neurotransmitters like serotonin and GABA can help mitigate stress responses, promoting relaxation.
  • Boosts Brain Power: Enhancing sleep quality and reducing stress can contribute to improved cognitive function and mental clarity.
  • Can Help With Depression: DSIP’s ability to promote better sleep and reduce stress may indirectly support mood regulation and alleviate symptoms of depression.
  • Provides Support for Alcohol and Drug Withdrawal: DSIP’s calming effects and support for sleep quality may assist individuals undergoing withdrawal from substances by promoting rest and relaxation.
  • Stimulates LH and GHRH: DSIP has been shown to influence hormone release, including LH (Luteinizing Hormone), which is involved in reproductive health, and GHRH (Growth Hormone Releasing Hormone), which regulates growth hormone secretion.

Additional Info

Properties

  • DSIP Chemical Formula: C35H48N10O15
  • DSIP Molecular Weight: 848.81 g/mol
  • DSIP Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
  • Total Amount of the Active Ingredient: 5 mg (1 vial)
  • Shelf Life: 36 months

 

Shipping

  • USA
  • Canada

 

Disclaimer

  • This information does not substitute medical advice, diagnosis, or treatment.
  • Seek advice from a physician or qualified healthcare provider for medical conditions.
  • Products are sold for research purposes only, not for human consumption.
  • Not approved by the FDA for human use.

 

Additional Label & Product Information

  • Essential Warning:
    • For research or laboratory use only.
  • Using Instructions:
    • Avoid skin and eye contact; wash with water if contact occurs.
    • Seek medical advice if unwell or accidental ingestion occurs.
    • Store at room temperature upon receipt; avoid frequent freeze-thaw cycles.
  • Product Disclaimer:
    • Not intended to diagnose, treat, cure, or prevent any disease.
    • Apply as per specific research or laboratory protocols.

 

Resources

  1. Monnier M, Dudler L, Gächter R, Maier PF, Tobler HJ, Schoenenberger GA. The delta sleep inducing peptide (DSIP): Comparative properties of the original and synthetic nonapeptide. Experientia. 1977 Apr 15;33(4):548-52. doi: 10.1007/BF01922266. PMID: 862769.
  2. Koval’zon VM. DSIP: Peptide of sleep or unknown hypothalamic hormone? Zh Evol Biokhim Fiziol. 1994 Mar-Apr;30(2):310-9. Russian. PMID: 7817664.
  3. Nakagaki K, Ebihara S, Usui S, Honda Y, Takahashi Y, Kato N. Effects of intraventricular injection of anti-DSIP serum on sleep in rats. Yakubutsu Seishin Kodo. 1986 Jun;6(2):259-65. Japanese. PMID: 3776352.
  4. Iyer KS, Marks GA, Kastin AJ, McCann SM. Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat. Proc Natl Acad Sci U S A. 1988 May;85(10):3653-6. doi: 10.1073/pnas.85.10.3653. PMID: 3368469; PMCID: PMC280272.
  5. Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA. Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. Int J Clin Pharmacol Ther Toxicol. 1981 Aug;19(8):341-5. PMID: 6895513.
  6. Larbig W, Gerber WD, Kluck M, Schoenenberger GA. Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes: A clinical pilot study. Eur Neurol. 1984;23(5):372-85. doi: 10.1159/000115716. PMID: 6548970.
  7. Dick P, Grandjean ME, Tissot R. Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors. Neuropsychobiology. 1983;10(4):205-8. doi: 10.1159/000118012. PMID: 6328354.
  8. Lesch KP, Widerlöv E, Ekman R, Laux G, Schulte HM, Pfüller H, Beckmann H. Delta sleep-inducing peptide response to human corticotropin-releasing hormone (CRH) in major depressive disorder: Comparison with CRH-induced corticotropin and cortisol secretion. Biol Psychiatry. 1988 Jun;24(2):162-72. doi: 10.1016/0006-3223(88)90271-5. PMID: 2839244.
  9. Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II. Delta sleep inducing peptide (DSIP): Effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003 Feb;24(2):307-11. doi: 10.1016/s0196-9781(03)00040-8. PMID: 12668217.

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