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Semaglutide (5mg)

Original price was: $133.00.Current price is: $119.00.

  • Semaglutide is derived from the natural peptide GLP-1, which lowers blood sugar levels and enhances insulin secretion.
  • Research indicates that Semaglutide may improve heart, liver, and lung function, and potentially mitigate the effects of Alzheimer’s disease.
  • Initially developed to combat type 2 diabetes.

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Description

  • Semaglutide is derived from the natural peptide GLP-1, which lowers blood sugar levels and enhances insulin secretion.
  • Research indicates that Semaglutide may improve heart, liver, and lung function, and potentially mitigate the effects of Alzheimer’s disease.
  • Initially developed to combat type 2 diabetes.

How It Works

  • Semaglutide mimics the natural GLP-1 hormone released in the gut after eating.
  • It targets brain centers that regulate appetite and slows gastric emptying, effectively reducing appetite.
  • Semaglutide stimulates insulin production, facilitating the movement of sugar from the blood into tissues, improving overall blood sugar control and utilization.

Research Benefits

  • Promotes fat loss.
  • Manages appetite effectively.
  • Effective in combating type 2 diabetes.
  • Potential to prevent cognitive decline.
  • Lowers blood pressure.
  • Reduces the risk of cardiovascular disease.

Additional Info

Properties

  • Chemical Formula: C187H291N45O59
  • Molecular Mass: 4114 g/mol
  • Synonyms: NN9535, Ozempic, Wegovy, Rybelsus
  • CAS Number: 910463-68-2
  • PubChem: 56843331
  • Total Amount of the Active Ingredient: 2 mg (1 vial)
  • Shelf Life: 36 months

 

Shipping

  • USA
  • Canada
  • Shipping Disclaimer: If your shipment was seized (International Orders), we will provide a 50% discount applicable on your next purchase. Please contact us for more information.

 

Disclaimer

The information above does not substitute medical advice, diagnosis, or treatment. If you have questions about a medical condition, consult your physician or qualified healthcare provider promptly. Never delay seeking medical advice based on information you have read or seen. We assume no liability for the use of our research compounds and products. These items are sold exclusively for research purposes. We do not endorse personal use.

 

Additional Label and Product Information

Essential warning:

The chemicals contained are for research or laboratory use only. Not approved by the FDA for human consumption.

Using instructions:

  • Avoid skin and eye contact. Rinse immediately with plenty of water if contact occurs.
  • Seek medical advice if feeling unwell or in case of accidental ingestion.
  • Store the lyophilized (freeze-dried) peptide at room temperature upon receipt. Avoid repeated freeze-thaw cycles for peptide stability.

 

Product Disclaimer:

This product is not intended to diagnose, treat, cure, or prevent any disease. Apply only as directed by specific research or laboratory protocols.

 

Resources

  1. Holst JJ. From the Incretin Concept and the Discovery of GLP-1 to Today’s Diabetes Therapy. Front Endocrinol (Lausanne). 2019 Apr 26;10:260. doi: 10.3389/fendo.2019.00260. PMID: 31080438; PMCID: PMC6497767.
  2. Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007 Oct;87(4):1409-39. doi: 10.1152/physrev.00034.2006. PMID: 17928588.
  3. Yang Z, Chen M, Carter JD, Nunemaker CS, Garmey JC, Kimble SD, Nadler JL. Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1017-22. doi: 10.1016/j.bbrc.2006.03.177. PMID: 16643856.
  4. Tang-Christensen M, Larsen PJ, Thulesen J, Rømer J, Vrang N. The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat Med. 2000 Jul;6(7):802-7. doi: 10.1038/77535. PMID: 10888930.
  5. van Bloemendaal L, IJzerman RG, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML, Veltman DJ, Diamant M. GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans. Diabetes. 2014 Dec;63(12):4186-96. doi: 10.2337/db14-0849.
  6. Ard J, Fitch A, Fruh S, Herman L. Weight Loss and Maintenance Related to the Mechanism of Action of Glucagon-Like Peptide 1 Receptor Agonists. Adv Ther. 2021 Jun;38(6):2821-2839. doi: 10.1007/s12325-021-01710-0.
  7. Friedrichsen M, Breitschaft A, Tadayon S, Wizert A, Skovgaard D. The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity. Diabetes Obes Metab. 2021 Mar;23(3):754-762. doi: 10.1111/dom.14280.
  8. Gros R, You X, Baggio LL, Kabir MG, Sadi AM, Mungrue IN, Parker TG, Huang Q, Drucker DJ, Husain M. Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology. 2003 Jun;144(6):2242-52. doi: 10.1210/en.2003-0007. PMID: 12746281.
  9. During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ, Haile CN. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med. 2003 Sep;9(9):1173-9. doi: 10.1038/nm919. PMID: 12925848.
  10. Perry T, Haughey NJ, Mattson MP, Egan JM, Greig NH. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther. 2002 Sep;302(3):881-8. doi: 10.1124/jpet.102.037481. PMID: 12183643.
  11. Perry TA, Greig NH. A new Alzheimer’s disease interventive strategy: GLP-1. Curr Drug Targets. 2004 Aug;5(6):565-71. doi: 10.2174/1389450043345245. PMID: 15270203.
  12. Graaf C, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, Ahn JM, Liao J, Fletcher MM, Yang D, Brown AJ, Zhou C, Deng J, Wang MW. Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacol Rev. 2016 Oct;68(4):954-1013. doi: 10.1124/pr.115.011395.
  13. Shao S, Nie M, Chen C, Chen X, Zhang M, Yuan G, Yu X, Yang Y. Protective action of liraglutide in beta cells under lipotoxic stress via PI3K/Akt/FoxO1 pathway. J Cell Biochem. 2014 Jun;115(6):1166-75. doi: 10.1002/jcb.24763.

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